Trapping of an open-channel blocker at the frog neuromuscular acetylcholine channel
نویسندگان
چکیده
منابع مشابه
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1986
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(86)83538-x